Acetil-CoA acetiltransferase, citosólica, também conhecida como acetoacetil-CoA tiolase citosólica, é uma enzima que em humanos é codificada pelo geneACAT2 (acetil-Coenzima A acetiltransferase 2).[2]
Locke JA, Wasan KM, Nelson CC, Guns ES, Leon CG (janeiro de 2008). «Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT)». The Prostate. 68 (1): 20–33. PMID18000807. doi:10.1002/pros.20674
He X, Lu Y, Saha N, Yang H, Heng CK (dezembro de 2005). «Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks». Human Genetics. 118 (3-4): 393–403. PMID16195894. doi:10.1007/s00439-005-0055-3
Yamada Y, Matsuo H, Warita S, Watanabe S, Kato K, Oguri M, Yokoi K, Metoki N, Yoshida H, Satoh K, Ichihara S, Aoyagi Y, Yasunaga A, Park H, Tanaka M, Nozawa Y (novembro de 2007). «Prediction of genetic risk for dyslipidemia». Genomics. 90 (5): 551–8. PMID17919884. doi:10.1016/j.ygeno.2007.08.001
Kursula P, Sikkilä H, Fukao T, Kondo N, Wierenga RK (março de 2005). «High resolution crystal structures of human cytosolic thiolase (CT): a comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I». Journal of Molecular Biology. 347 (1): 189–201. PMID15733928. doi:10.1016/j.jmb.2005.01.018
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM (dezembro de 2008). «Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations». Journal of Lipid Research. 49 (12): 2582–9. PMID18660489. doi:10.1194/jlr.M800232-JLR200
Pramfalk C, Angelin B, Eriksson M, Parini P (dezembro de 2007). «Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells». Biochemical and Biophysical Research Communications. 364 (2): 402–9. PMID17950700. doi:10.1016/j.bbrc.2007.10.028
Yoshida T, Kato K, Yokoi K, Watanabe S, Metoki N, Satoh K, Aoyagi Y, Nishigaki Y, Nozawa Y, Yamada Y (maio de 2009). «Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension». Hypertension Research. 32 (5): 411–8. PMID19282863. doi:10.1038/hr.2009.22
Matsumoto K, Fujiwara Y, Nagai R, Yoshida M, Ueda S (fevereiro de 2008). «Expression of two isozymes of acyl-coenzyme A: cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma». International Journal of Urology. 15 (2): 166–70. PMID18269457. doi:10.1111/j.1442-2042.2007.01947.x
Yao XM, Wang CH, Song BL, Yang XY, Wang ZZ, Qi W, Lin ZX, Chang CC, Chang TY, Li BL (dezembro de 2005). «Two human ACAT2 mRNA variants produced by alternative splicing and coding for novel isoenzymes». Acta Biochimica et Biophysica Sinica. 37 (12): 797–806. PMID16331323. doi:10.1111/j.1745-7270.2005.00118.x
Ohta T, Takata K, Katsuren K, Fukuyama S (junho de 2004). «The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects». Biochimica et Biophysica Acta. 1682 (1-3): 56–62. PMID15158756. doi:10.1016/j.bbalip.2004.01.008
Ruaño G, Bernene J, Windemuth A, Bower B, Wencker D, Seip RL, Kocherla M, Holford TR, Petit WA, Hanks S (fevereiro de 2009). «Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone». Clinica Chimica Acta; International Journal of Clinical Chemistry. 400 (1-2): 48–55. PMID18996102. doi:10.1016/j.cca.2008.10.009
Jiang ZY, Jiang CY, Wang L, Wang JC, Zhang SD, Einarsson C, Eriksson M, Han TQ, Parini P, Eggertsen G (janeiro de 2009). «Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients». Biochemical and Biophysical Research Communications. 379 (1): 49–54. PMID19071091. doi:10.1016/j.bbrc.2008.11.131
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). «Large-scale mapping of human protein-protein interactions by mass spectrometry». Molecular Systems Biology. 3 (1). 89 páginas. PMC1847948. PMID17353931. doi:10.1038/msb4100134