A proteína 1 da haste helicoidal de espiral enrolada, também conhecida como CCHCR1, é uma proteína que em humanos é codificada pelo gene CCHCR1.[3][4][5]
Oka A, Tamiya G, Tomizawa M, Ota M, Katsuyama Y, Makino S, Shiina T, Yoshitome M, Iizuka M, Sasao Y, Iwashita K, Kawakubo Y, Sugai J, Ozawa A, Ohkido M, Kimura M, Bahram S, Inoko H (1999). «Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene». Hum. Mol. Genet. 8 (12): 2165–70. PMID10545595. doi:10.1093/hmg/8.12.2165
Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, Saarialho-Kere U, Kere J (2000). «A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele». Hum. Mol. Genet. 9 (10): 1533–42. PMID10888604. doi:10.1093/hmg/9.10.1533
O'Brien KP, Holm SJ, Nilsson S, Carlén L, Rosenmüller T, Enerbäck C, Inerot A, Ståhle-Bäckdahl M (2001). «The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene». J. Invest. Dermatol. 116 (5): 750–4. PMID11348465. doi:10.1046/j.0022-202x.2001.01323.x
Asumalahti K, Veal C, Laitinen T, Suomela S, Allen M, Elomaa O, Moser M, de Cid R, Ripatti S, Vorechovsky I, Marcusson JA, Nakagawa H, Lazaro C, Estivill X, Capon F, Novelli G, Saarialho-Kere U, Barker J, Trembath R, Kere J (2002). «Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus». Hum. Mol. Genet. 11 (5): 589–97. PMID11875053. doi:10.1093/hmg/11.5.589
Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS (2002). «Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase». J. Biol. Chem. 277 (31): 28051–7. PMID12023963. doi:10.1074/jbc.M202665200
Sugawara T, Shimizu H, Hoshi N, Nakajima A, Fujimoto S (2003). «Steroidogenic acute regulatory protein-binding protein cloned by a yeast two-hybrid system». J. Biol. Chem. 278 (43): 42487–94. PMID12909641. doi:10.1074/jbc.M302291200
Suomela S, Elomaa O, Asumalahti K, Kariniemi AL, Karvonen SL, Peltonen J, Kere J, Saarialho-Kere U (2003). «HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes». J. Invest. Dermatol. 121 (6): 1360–4. PMID14675183. doi:10.1046/j.1523-1747.2003.12642.x
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). «Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation». Nat. Biotechnol. 22 (6): 707–16. PMID15146197. doi:10.1038/nbt971
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). «A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration». Cell. 125 (4): 801–14. PMID16713569. doi:10.1016/j.cell.2006.03.032
Chang J, Nicolas E, Marks D, Sander C, Lerro A, Buendia MA, Xu C, Mason WS, Moloshok T, Bort R, Zaret KS, Taylor JM (2004). «miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1». RNA Biol. 1 (2): 106–13. PMID17179747. doi:10.4161/rna.1.2.1066
Tiala I, Suomela S, Huuhtanen J, Wakkinen J, Hölttä-Vuori M, Kainu K, Ranta S, Turpeinen U, Hämäläinen E, Jiao H, Karvonen SL, Ikonen E, Kere J, Saarialho-Kere U, Elomaa O (2007). «The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes». J. Mol. Med. 85 (6): 589–601. PMID17221218. doi:10.1007/s00109-006-0155-0
Suomela S, Kainu K, Onkamo P, Tiala I, Himberg J, Koskinen L, Snellman E, Karvonen SL, Karvonen J, Uurasmaa T, Reunala T, Kivikäs K, Jansén CT, Holopainen P, Elomaa O, Kere J, Saarialho-Kere U (2007). «Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis». Acta Derm. Venereol. 87 (2): 127–34. PMID17340018. doi:10.2340/00015555-0184
Elomaa O, Majuri I, Suomela S, Asumalahti K, Jiao H, Mirzaei Z, Rozell B, Dahlman-Wright K, Pispa J, Kere J, Saarialho-Kere U (agosto de 2004). «Transgenic mouse models support HCR as an effector gene in the PSORS1 locus». Human Molecular Genetics. 13 (15): 1551–61. PMID15190014. doi:10.1093/hmg/ddh178