CCHCR1

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CCHCR1
Identificadores
Nomes alternativosCCHCR1
IDs externosOMIM: 605310 HomoloGene: 10396 GeneCards: CCHCR1
Doenças Geneticamente Relacionadas
exantema, cancro da próstata, exantema[1]
Wikidata
Ver/Editar Humano

A proteína 1 da haste helicoidal de espiral enrolada, também conhecida como CCHCR1, é uma proteína que em humanos é codificada pelo gene CCHCR1.[3][4][5]

Referências

  1. «Doenças geneticamente associadas a CCHCR1 ver/editar referências no wikidata» 
  2. «Human PubMed Reference:» 
  3. «Entrez Gene: CCHCR1 coiled-coil alpha-helical rod protein 1» 
  4. Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, Saarialho-Kere U, Kere J (junho de 2000). «A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele». Hum. Mol. Genet. 9 (10): 1533–42. PMID 10888604. doi:10.1093/hmg/9.10.1533 
  5. Oka A, Tamiya G, Tomizawa M, Ota M, Katsuyama Y, Makino S, Shiina T, Yoshitome M, Iizuka M, Sasao Y, Iwashita K, Kawakubo Y, Sugai J, Ozawa A, Ohkido M, Kimura M, Bahram S, Inoko H (novembro de 1999). «Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene». Hum. Mol. Genet. 8 (12): 2165–70. PMID 10545595. doi:10.1093/hmg/8.12.2165 

Leitura adicional[editar | editar código-fonte]

  • Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). «Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence» (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098 
  • Oka A, Tamiya G, Tomizawa M, Ota M, Katsuyama Y, Makino S, Shiina T, Yoshitome M, Iizuka M, Sasao Y, Iwashita K, Kawakubo Y, Sugai J, Ozawa A, Ohkido M, Kimura M, Bahram S, Inoko H (1999). «Association analysis using refined microsatellite markers localizes a susceptibility locus for psoriasis vulgaris within a 111 kb segment telomeric to the HLA-C gene». Hum. Mol. Genet. 8 (12): 2165–70. PMID 10545595. doi:10.1093/hmg/8.12.2165 
  • Asumalahti K, Laitinen T, Itkonen-Vatjus R, Lokki ML, Suomela S, Snellman E, Saarialho-Kere U, Kere J (2000). «A candidate gene for psoriasis near HLA-C, HCR (Pg8), is highly polymorphic with a disease-associated susceptibility allele». Hum. Mol. Genet. 9 (10): 1533–42. PMID 10888604. doi:10.1093/hmg/9.10.1533 
  • O'Brien KP, Holm SJ, Nilsson S, Carlén L, Rosenmüller T, Enerbäck C, Inerot A, Ståhle-Bäckdahl M (2001). «The HCR gene on 6p21 is unlikely to be a psoriasis susceptibility gene». J. Invest. Dermatol. 116 (5): 750–4. PMID 11348465. doi:10.1046/j.0022-202x.2001.01323.x 
  • Asumalahti K, Veal C, Laitinen T, Suomela S, Allen M, Elomaa O, Moser M, de Cid R, Ripatti S, Vorechovsky I, Marcusson JA, Nakagawa H, Lazaro C, Estivill X, Capon F, Novelli G, Saarialho-Kere U, Barker J, Trembath R, Kere J (2002). «Coding haplotype analysis supports HCR as the putative susceptibility gene for psoriasis at the MHC PSORS1 locus». Hum. Mol. Genet. 11 (5): 589–97. PMID 11875053. doi:10.1093/hmg/11.5.589 
  • Xu YC, Wu RF, Gu Y, Yang YS, Yang MC, Nwariaku FE, Terada LS (2002). «Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase». J. Biol. Chem. 277 (31): 28051–7. PMID 12023963. doi:10.1074/jbc.M202665200 
  • Sugawara T, Shimizu H, Hoshi N, Nakajima A, Fujimoto S (2003). «Steroidogenic acute regulatory protein-binding protein cloned by a yeast two-hybrid system». J. Biol. Chem. 278 (43): 42487–94. PMID 12909641. doi:10.1074/jbc.M302291200 
  • Suomela S, Elomaa O, Asumalahti K, Kariniemi AL, Karvonen SL, Peltonen J, Kere J, Saarialho-Kere U (2003). «HCR, a candidate gene for psoriasis, is expressed differently in psoriasis and other hyperproliferative skin disorders and is downregulated by interferon-gamma in keratinocytes». J. Invest. Dermatol. 121 (6): 1360–4. PMID 14675183. doi:10.1046/j.1523-1747.2003.12642.x 
  • Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (2004). «Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation». Nat. Biotechnol. 22 (6): 707–16. PMID 15146197. doi:10.1038/nbt971 
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). «A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration». Cell. 125 (4): 801–14. PMID 16713569. doi:10.1016/j.cell.2006.03.032 
  • Chang J, Nicolas E, Marks D, Sander C, Lerro A, Buendia MA, Xu C, Mason WS, Moloshok T, Bort R, Zaret KS, Taylor JM (2004). «miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1». RNA Biol. 1 (2): 106–13. PMID 17179747. doi:10.4161/rna.1.2.1066 
  • Tiala I, Suomela S, Huuhtanen J, Wakkinen J, Hölttä-Vuori M, Kainu K, Ranta S, Turpeinen U, Hämäläinen E, Jiao H, Karvonen SL, Ikonen E, Kere J, Saarialho-Kere U, Elomaa O (2007). «The CCHCR1 (HCR) gene is relevant for skin steroidogenesis and downregulated in cultured psoriatic keratinocytes». J. Mol. Med. 85 (6): 589–601. PMID 17221218. doi:10.1007/s00109-006-0155-0 
  • Suomela S, Kainu K, Onkamo P, Tiala I, Himberg J, Koskinen L, Snellman E, Karvonen SL, Karvonen J, Uurasmaa T, Reunala T, Kivikäs K, Jansén CT, Holopainen P, Elomaa O, Kere J, Saarialho-Kere U (2007). «Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis». Acta Derm. Venereol. 87 (2): 127–34. PMID 17340018. doi:10.2340/00015555-0184 
  • Elomaa O, Majuri I, Suomela S, Asumalahti K, Jiao H, Mirzaei Z, Rozell B, Dahlman-Wright K, Pispa J, Kere J, Saarialho-Kere U (agosto de 2004). «Transgenic mouse models support HCR as an effector gene in the PSORS1 locus». Human Molecular Genetics. 13 (15): 1551–61. PMID 15190014. doi:10.1093/hmg/ddh178 
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